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Mathematical analyses
To look at associations between diet and coronary arrest, we utilized Cox proportional problems activities stratified from the decades (mo) and you will pursue-upwards cycle so you can imagine RRs and you may 95% CIs. Players was indeed divided in to quintiles out-of cumulative average intake from magnesium, potassium, and you can calcium supplements to reduce the within-people variation and best depict enough time-identity consumption ( 18). A blended nutrient diet plan get regarding magnesium, potassium, and you will calcium was basically computed because of the delegating points to per quintile and you may summing the fresh circumstances. Participants throughout the reasonable quintile (quintile step 1) out of magnesium, potassium, or calcium supplements consumption acquired 1 point per nutrient, players within the next quintile (quintile dos) received dos issues, an such like. Collective averages were computed by using the brand new indicate of all of the reported FFQ intakes up to the beginning of for every 2-y realize-right up period. The latest cumulative average consumption was used in order to anticipate heart attack occurrence off the full time of history came back survey through to the 2nd go after-up stage.
Multivariate habits were adjusted to have ages (mo) and you may schedule go out Gay dating sites (2-y time durations) and included intakes of full energy (kcal), liquor (g/d), cigarette smoking, Body mass index, physical working out, parental reputation of early myocardial infarction, postmenopausal hormonal cures fool around with, thiazide use, aspirin have fun with, multi vitamin use, and history of diabetic issues, blood pressure levels, and you can hypercholesterolemia in the baseline. To test to have good linear pattern, we tasked for every single quintile this new average really worth and you will modeled that it changeable since a continuous variable. I checked the possibility departure off linearity that with an odds proportion try to possess review out-of an unit into the linear title which have a design like the linear name together with minimal cubic spline changes ( 19). I including used analyses that included all the step three nutrition additionally. Magnesium and you will potassium consumption was indeed highly coordinated (r = 0.79 on the NHS I; r = 0.73 about NHS II), and you can correlations anywhere between calcium and you will potassium consumption (roentgen = 0.49 regarding NHS I; roentgen = 0.41 about NHS II), whereas between calcium and you may magnesium consumption (r = 0.54 throughout the NHS We; r = 0.56 on the NHS II) had been modest. This new Q shot was used to check for the heterogeneity ranging from the new NHS I and NHS II. RRs (±SEs) for every single quintile off each cohort was pooled inside repaired-effects patterns in order to determine summary rates ( 20). Furthermore, the up-to-date meta-studies observed simple habit ( 20) away from testing to possess heterogeneity utilising the Q ensure that you having fun with repaired outcomes design in order to make summary prices when no anywhere between-degree heterogeneity was apparent; or even an arbitrary-outcomes model was applied.
To examine the potential effect modification of the association between dietary minerals and stroke risk by age, hypertension, and diabetes, we stratified our multivariate model on age (<60 compared with ?60 y), hypertension (yes compared with no), and diabetes (yes compared with no) and separately tested the significance of an interaction by using a likelihood ratio test for the comparison of the model with interaction terms to the model with only main effects. All P values were 2-sided, and analyses were conducted with SAS 9.2 software (SAS Institute Inc.).
Overall performance
While in the 31 y out of realize-right up regarding 1980 as a result of 2010 regarding the NHS I and twenty two y away from follow-right up out-of 1989 by way of 2011 throughout the NHS II, all in all, 3780 experience stroke times was in fact ascertained. Ones circumstances, 3237 incident strokes was reported about NHS I (and 1664 ischemic, 544 hemorrhagic, and 1029 unspecified shots), and you will 543 incident strokes was basically noted about NHS II (in addition to 186 ischemic, ninety-five hemorrhagic, and you may 265 unspecified strokes). Age-standardized attributes away from investigation people from the midpoint while in the realize-upwards inside 1994 for the NHS We plus 1995 to own the brand new NHS II are shown inside Dining table step 1. Females which have highest nutrient intake was expected to explore aspirin, vitamins, and postmenopausal hormones cures, even more myself energetic, less likely to be newest smokers than just had been females which have all the way down mineral consumption. Analysis for females throughout the NHS I and you can NHS II was basically combined just like the i failed to to see a serious ranging from-data heterogeneity (Q-figure P > 0.05).
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